TLS have also been detected in the pancreas of lupus-prone mice by single photon emission computed tomography (SPECT) upon intraperitoneal injection of 99mTC labelled Albumin Nanocoll and confirmed by immunohistochemistry (145) In humans, it has been found that LN patients have TLS in different maturation states, with its presence being correlated with levels of serum CXCL13, which might suggest that CXCL13 produced by FDC might be involved in TLS development (146). The gene discussed is CXCL13; the disease is systemic lupus erythematosus.