In Liang et al.’s study, a core-shell structured upconversion nanocrystals-dendrimer complex targeting mitochondria and overcoming tumor hypoxia enhanced the efficacy of anticancer photodynamic therapy; catalytic degradation of hydrogen peroxide (H2O2) by catalase overcame tumor hypoxia and mitochondrial targeting, significantly enhancing PDT efficacy and offering a new paradigm for cargo delivery (84). This evidence concerns the gene CAT and neoplasm.