Moreover, Aryl Hydrocarbon Receptor Interacting Protein (AIP) can inhibit IRF7 by antagonizing its nuclear localization, hindering IRF7-induced IFN-I production, reducing immune responses, and promoting aberrant inflammation (75).In this study, IRF7 was identified as a critical gene for IDD through PPI network analysis and was significantly up-regulated in IDD samples. Here, AIP is linked to intervertebral disk degenerative disorder.