IRF7 and intervertebral disk degenerative disorder: IRF7 exhibits a significant negative correlation with HALLMARK_KRAS_SIGNALING_UP_PATHWAY, and down-regulation of HALLMARK_KRAS_SIGNALING_UP_PATHWAY has also been observed in IDD, suggesting that IRF7’s promotion of IDD may be mediated by inhibition of the KRAS pathway (Figure 9B).