GSVA supported the significant correlation between POLR2A and numerous Hallmark pathways enriched in the IDD group, indicating that abnormalities in POLR2A can lead to changes in multiple pathways, such as HALLMARK_MITOTIC_SPINDLE and HALLMARK_KARS_SIGNALING_UP, thereby affecting IDD progression. The gene discussed is POLR2A; the disease is intervertebral disk degenerative disorder.