CD4 and systemic lupus erythematosus: Furthermore, several studies identified a statistically significant relationship between clinical remission and immune-resolution biomarkers [e.g., imbalanced Tfh/Treg ratio associated with high disease activity [SELENA-SLEDAI] in SLE (12), IL-22 levels correlated with disease activity [EASI and SCORAD] in atopic dermatitis (25), and baseline CD4 Treg negatively correlated with disease activity [DAS28] in rheumatoid arthritis (14)].