Furthermore, another group demonstrated that nobiletin, which exerts memory-improving effects in various animal models of dementia, enhanced protein kinase A (PKA)/ERK/CREB signaling in PC12D cells and cultured rat hippocampal neurons and induced long-term potentiation by activating the PKA-dependent phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR1 in hippocampus slices [35]. The gene discussed is CREB1; the disease is dementia.