Further supporting the link between HO-1 and α-synuclein, HMOX1 overexpression from embryogenesis until 12 months of age, as seen in the GFAP.HMOX10–12 m mouse model of schizophrenia, similarly resulted in significant elevation of α-synuclein mRNA and protein [80]. This evidence concerns the gene HMOX1 and schizophrenia.