Intervention in the caspase-1/IL-1β/IL-1R1 feedback signaling by inhibition of caspase-1 as shown in this study or by the IL-1 receptor as we previously reported prevents Müller cell death in diabetic retinopathy demonstrating the importance of this signaling pathway to Müller cell viability (Feenstra et al., 2013). Here, IL1R1 is linked to diabetic retinopathy.