Taken together, this indicates that hyperglycemia induces caspase-1 activation and IL-1β production initiating a seemingly IL-1β driven caspase-1/IL-1β/IL-1R1 feedback cycle that is detrimental to the viability of retinal cells such as Müller cells and promotes the development and progression of diabetic retinopathy (Figure 7). Here, CASP1 is linked to diabetic retinopathy.