Therefore, this study aimed to identify (Stitt et al., 2013) how caspase-1 activity is induced and sustained in hyperglycemic conditions in vivo and in vitro since this process seemingly contributes to chronic inflammation seen in diabetic retinopathy and (Abcouwer, 2012) whether RIP2 acts a potential regulator of chronic caspase-1 activation. Here, CASP1 is linked to diabetic retinopathy.