ENO1 and ductal breast carcinoma in situ: In the more aggressive ductal carcinoma, ENO1 is overexpressed and clusters with angiogenesis, apoptosis, cell proliferation, cytotoxicity, several signalling, and epigenetic pathways in the early-stage ductal carcinoma in situ (DCIS), whereas more pathways are recruited in ductal carcinoma and high-grade tumours.