A complex relationship of ENO1 with immune pathways was revealed by this study to complement other studies evaluating the role of ENO1 in the tumour–immune microenvironment (TME).13,38,39 Underexpression occurs in good prognostic subtypes of breast carcinoma, whereas overexpression of the pathways occurs in triple-negative breast carcinomas. The gene discussed is ENO1; the disease is neoplasm.