MethSurv (https://biit.cs.ut.ee/methsurv) using data from Breast Cancers obtained from the Cancer Genome Atlas (BRCA-TCGA) (n = 782) was used to access ENO1 DNA methylation (Figure 7A) and its effect on survival.36 However, 4 loci were identified where low methylation is linked to worse survival outcome (Figure 7B; cg20971527: HR 0.461, CI 0.312–0.681, LR-test P = .00014; cg09819654: HR 0.48, CI 0.291–0.792, LR-test P = .0021; cg06972019: HR 0.662, CI 0.446–0.981, LR-test P = .038; cg13785123: HR 0.594, CI 0.36–0.978, LR-test P = .031). The gene discussed is ENO1; the disease is breast carcinoma.