In the more aggressive ductal carcinoma, ENO1 is overexpressed and clusters with angiogenesis, apoptosis, cell proliferation, cytotoxicity, several signalling, and epigenetic pathways in the early-stage ductal carcinoma in situ (DCIS), whereas more pathways are recruited in ductal carcinoma and high-grade tumours. The gene discussed is ENO1; the disease is breast ductal adenocarcinoma.