ENO1 is overexpressed at mRNA level in BCs in comparison to normal tissue (Tumour: n = 1097, Normal: n = 403; P = 1.49 × 10−16; Figure 1A) and its expression is significantly higher at PAM50 basal (n = 172) and HER2 (n = 73) subtypes compared with luminal A (n = 508), luminal B (n = 191), and normal (n = 137) (Kruskal–Wallis H-test P = 4.79 × 10−84; Figure 1B). This evidence concerns the gene ERBB2 and neoplasm.