Furthermore, colonization of mice with M. restricta has been observed to exacerbate the severity of dextran sulfate sodium-induced colitis (Limon et al., 2019).In addition, Malassezia species infiltrate pancreatic ductal adenocarcinoma tumors in both humans and mice, contributing to disease progression by activating the complement cascade via mannose-binding lectin (Aykut et al., 2019). Here, MBL2 is linked to pancreatic ductal adenocarcinoma.