FZD1 and myocardial infarction: Additionally, UM206 has demonstrated inhibitory effects on FZD1 and FZD2 receptors in the presence of WNT3A, but not on FZD3 or FZD4, indicating its selectivity.Researchers decided to investigate the effects of UM206 after myocardial infarction (MI) in mice due to its significant impact on the WNT signaling pathway.