SFRP1 and myocardial infarction: SFRP1 inhibits this pathway, providing significant protection to aging hearts from acute myocardial infarction (AMI) injury.As a small molecule gene therapy, SFRP1 has the potential to enhance heart function, reduce myocardial fibrosis, block cardiomyocyte apoptosis, and mitigate AMI injury in aged animals.