Glutamate, in turn, is further converted to 2‐oxoglutarate (2‐OG, also known as α‐ketoglutarate) by glutamate dehydrogenase 1 (GLUD1) that enters the citric acid cycle (TCA cycle) or is metabolized to glutathione (GSH) by glutamate‐cysteine ligase catalytic subunit (GCLC) for maintaining cellular redox homeostasis.[10, 13] Cancer cells manage to elevate GLS expression or enhance glutamine flux to fuel the synthesis of amino acids, nucleotides, or fatty acids. This evidence concerns the gene GLUD1 and cancer.