GLS and neoplasm: The Glu‐GSH flux is important for maintaining the redox balance by fueling the GSH production.[10b] Previous studies have found that knockdown of GLS leads to GSH depletion and causes the accumulation of reactive oxygen species (ROS) in tumor cells.[38] We hypothesized that glutamine depletion may inhibit Glu‐GSH flux, and thus elevate the level of ROS, leading to increased tumor antigen presentation and anti‐tumor immune response.