Administration of chloroquine 3 h before or 6 h after CLP surgery markedly improved survival, indicating its potential as both a preventive and therapeutic agent in sepsis.[40] Eritoran tetrasodium (E5564), a TLR4 antagonist, was shown to be a promising therapeutic candidate but failed in clinical trials, possibly due to late administration.[41] Thus, the timing of TDIP administration should also be carefully evaluated. This evidence concerns the gene TLR4 and Sepsis.