2016; Xia et al. 2022). Immunohistochemical results showed that the area of Aβ1–42‐positive staining (brown) in the colon of mice with AD increased compared to the control group, and the area of positive staining decreased after DSS intervention (Figure 8). The area of p‐tau‐positive staining (brown) in the colon of mice with AD increased compared to that in the control group and similarly decreased after DSS intervention (Figure 8). This evidence concerns the gene MAPT and Alzheimer disease.