In the present study, the Chinese herbal compound DSS with multitarget action was selected, which not only alleviated the age spots and NFTs in the brain AD mice but also played an excellent role in clearing intestinal Aβ and p‐tau deposition, which are related to DSS regulating intestinal microbial composition, protecting the intestinal barrier, and improving intestinal homeostasis. This evidence concerns the gene MAPT and Alzheimer disease.