Moreover, Shen et al. prepared an injectable copper-induced hydrogel containing PD-L1 antibody and nitric oxide (NO) donor, which could significantly increase apoptosis of tumor cells, induce immune cell death, and be able to increase infiltration of cytotoxic T-lymphocytes (CTLs) by photothermal therapy, thereby reversing TME to improve the therapeutic efficacy of anti-PD-L1 in vivo [232]. Here, CD274 is linked to neoplasm.