A study found that DLD was lowly expressed in ACC, bladder cancer (BLCA), ccRCC, AML, PCPG, and THCA, and highly expressed in BRCA, CCA, DLBC, GBM, KICH, KIRP, HCC, LUAD, LUSC, PAAD, PRAD, READ, SKCM, STAD, TGCT, and THYM, in BLCA and UCS, high expression of DLD predicted poor prognosis, but upregulation of DLD expression had better prognostic value for ccRCC and KIRP. The gene discussed is DLD; the disease is nonpapillary renal cell carcinoma.