CD274 and acute myeloid leukemia: It has been found that the expression level of LIPT1 is high in OS [91] and AML [89], the low expression of LIPT1 is associated with poor prognosis in AML, in HCC, the expression level of LIPT1 is also high, and LIPT1 can promote the proliferation and migration of HCC cells and upregulation of LIPT1 expression is associated with poor prognosis in HCC [100, 101], and in melanoma, the upregulation of LIPT1 is positively correlated with PD-L1 expression, additionally, in melanoma patients, melanoma patients with higher levels of LIPT1 expression showed better prognosis [102].