CRGs are differentially expressed in AML patients and are highly correlated with poor prognosis, CRGs LIPT1, MTF1, GLS, and CDKN2A are highly expressed in AML, whereas FDX1, LIAS, DLD, DLAT, PDHA1, SLC31A1, and ATP7B are lowly expressed in AML, high expression of MTF1 and low expression of LIPT1 are associated with poorer prognosis in AML patients [89]. This evidence concerns the gene GLS and acute myeloid leukemia.