Since genetic polymorphisms is known to contribute to susceptibility, severity of infectious autoimmune diseases and other complex diseases [13], this study aimed to address this gap in knowledge by investigating the involvement of gene polymorphisms in interleukin-4 (IL-4) and its receptor alpha (IL-4Rα) gene regions in uncomplicated malaria (UM) in paediatric Ghanaian patients. Here, IL4R is linked to malaria.