We anticipated (a) subjects with a history of hypertension would exhibit increased PVS volumes at baseline and more pronounced volume increases over time than normotensive individuals, (b) WMH of presumed vascular origin would relate to PVS dynamics, and (c) diagnosis (MCI and AD versus controls) and presence of AD biomarkers (amyloid and/or tau positivity). Here, MAPT is linked to Alzheimer disease.