MYC and Miyoshi myopathy: Indeed, Ronca et al. showed that the inhibition of the FGF/FGFR system in MM cells by the pan-FGF trap molecule NSC12 and by the TK FGFR inhibitor BGJ398 results in the activation of GSK-3β kinase, thus triggering c-Myc ubiquitination and proteasomal degradation [19].