Furthermore, Zhang et al. showed that c-Myc can indirectly trigger FGFR activation in pancreatic cancer cells by inducing the transcription of the fibroblast growth factor binding protein 1 (FGFBP1) which binds and releases immobilized FGFs from the extracellular matrix and chaperons FGFs to their receptors thus enhancing FGF/FGFR signaling cascade [135]. The gene discussed is FGFBP1; the disease is familial pancreatic carcinoma.