MYC and Miyoshi myopathy: The mutational landscape of the events driving MM development is wide, but interestingly data from genomic and gene set enrichment analyses indicated that the oncogene MYC and its signature are mostly deregulated in active MM cases than in MGUS and SMM [46] (Fig. 2), suggesting that MYC deregulation may be one of the key events triggering the transition between MGUS to full-blown MM [47, 48].