Indeed, IMiDs induce the proteasome degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), thus downregulating the expression of IKZF1/3 target genes, including MYC and IRF4. In addition, other transcription factors like ETV4 [66] and BATF2 [67] have been recently identified to induce MYC expression independently of Ikaros axis, thus contributing to IMiD resistance in MM. This evidence concerns the gene MYC and Miyoshi myopathy.