While the top three candidate proteins (ANGPTL4, PTX3, and NCR1) showed little to no associations with targeted AD-specific biomarkers (Aß42/40 ratio, Aß42/40/t-tau ratio), each correlated positively with measures of neuronal injury (NfL) or inflammation (IL6), suggesting that the link between these proteins and cognitive impairment is unlikely to be mediated through known amyloidogenic pathways. The gene discussed is PTX3; the disease is Alzheimer disease.