PTX3 and Alzheimer disease: Compared to resilient APOEε4 carriers, non-resilient APOEε4 carriers also showed greater abundance of multiple proteins less well characterized in the AD/dementia literature, including a regulator of angiogenesis, glucose homeostasis, and lipid metabolism (ANGPTL4), an activator of complement signaling that is induced by pro-inflammatory cytokines (PTX3), and a natural killer (NK) cell receptor involved in the viral cellular defense response (NCR1).