For example, modulation of peripheral and CNS ANGPTL4, PTX3, and NCR1 levels in human induced pluripotent stem cell-derived neurons or transgenic mice models of amyloidosis (e.g., 5XFAD) or tauopathy (e.g., P301S) with humanized APOEε4 allele would shed additional light on the neurobiological pathways through which these proteins influence AD risk among APOEε4 carriers. This evidence concerns the gene PTX3 and Alzheimer disease.