In total, nine of these downstream molecules have been previously associated with AD, including CASP8, PLG, LPL, PLAT (downstream of ANGPTL4), IL12B, RELA (downstream of PTX3), MAPK1, MAPK8, and PLCG2 (downstream of NCR1; Fig. 6F). Here, PLCG2 is linked to Alzheimer disease.