TP53 and breast carcinoma: PPI network analysis revealed that tumor protein p53 (TP53), serine/threonine kinase 1 (AKT1), and epidermal growth factor receptor (EGFR) were the main hub targets i.e., the most interconnected nodes within the network, based on the degree of nodes sizes TP53 is highly related to breast cancer, as mutations in TP53 are found in around 30% of breast carcinomas, resulting in the loss of its function as a tumor-suppressing protein [86].