To optimize treatment intervals between rAd.DCN and NK cells, HCT116 tumor-bearing NPG mice were divided into three groups: CON group, rAd.DCN + NK group 1 (NK infusion from the 3rd day after rAd.DCN injection), and rAd.DCN + NK group 2 (NK infusion from the 6th day after rAd.DCN injection). Here, DCN is linked to neoplasm.