In addition to the enhancement of NK cells in proliferation, persistence and cytotoxic function combined with rAd.DCN, as well as the reversal of immunosuppressive TME, the mechanism by which rAd.DCN promotes the efficacy of NK cells may also lie in its direct lyse of tumor cells and the inhibitory effect of decorin genes on tumors by targeting and blocking pivotal signaling pathways, such as TGF-β, Met, wnt/β-catenin, and VEGF, which are associated with tumor immune escape and metastasis [35]. The gene discussed is DCN; the disease is neoplasm.