Correlation analyses of multiplexed IHC staining data revealed that YBC immune cells have highly intercorrelated molecular features, confirming the established correlative nature of immune checkpoint molecules, such as augmented PD-L1 staining, which is highly correlated with an increased number of exhausted CD8+ Tregs and immunosuppressive macrophages in the tumor parenchyma (Supplementary Fig. 2). This evidence concerns the gene CD8A and neoplasm.