Based on the clinical classification of breast cancer with ER, PR, HER2, and Ki-6748 statuses, 33 patients were classified as luminal A type (26.2%), 55 as luminal B type (43.7%), 10 as HER2 type (7.9%), and 25 as TNBC type (19.8%). The gene discussed is ESR1; the disease is breast cancer.