SMYD3 and hepatocellular carcinoma: Furthermore, SMYD3 binds and activates the Snail family transcriptional repressor 2 (SNAI2) promoter, leading to increased levels of H3K4me3, H3K9Ac, and H3K14Ac; thus, the coexpression of SMYD3 and ANKDH1 is associated with poor prognosis in hepatocellular carcinoma patients84.