WNK2 and Familial prostate cancer: In prostate cancer, treatment with S-(-)-oleocanthal (OC), which is a component of a Mediterranean extra virgin olive oil-rich diet, leads to decreased SMYD2 expression and regulation of the mechanistic target of rapamycin kinase (mTOR), mitogen-activated protein kinase (MAPK), and p65 signaling pathways, inhibiting prostate cancer growth both in vitro and in vivo50.