CLEC7A and infection: On the other hand, the interaction between Mincle and Fonsecaea pedrosoi and F. monophora, causative agents of chromoblastomycosis, is not sufficient to induce a protective immune response and contributes to chronicity of the infection, downregulating the immune response elicited by Dectin-1 and Dectin-2 against these pathogens (da Glória Sousa et al, 2011; Wevers et al, 2014; Wüthrich et al, 2015).