OLR1 and rheumatoid arthritis: In addition, LOX-1 expression has been detected in the chondrocytes of patients with rheumatoid arthritis (RA) and the stimulation of Human RA fibroblast-like synoviocytes with oxLDL leads to the production of matrix metalloproteinases, enzymes that degrade extracellular matrix (Ishikawa et al, 2012).