In the ovalbumin (OVA)-induced airway inflammation model, the absence of Dectin-1 attenuated the disease as a result of increased number of T-regulatory cells in the lungs, mesenteric lymph nodes and the colonic lamina propria, in a process regulated by intestinal commensal microbiota (Han et al, 2021). The gene discussed is CLEC7A; the disease is inflammatory response.