In contrast, using the SKG mouse model of autoimmune arthritis (mice genetically prone to develop arthritis), Dectin-1 recognition of zymosan or purified β-glucans such as curdlan exacerbated the disease after a single intraperitoneal injection, through the activation of Dectin-1–expressing antigen presenting cells (Yoshitomi et al, 2005). This evidence concerns the gene CLEC7A and Arthritis.