Plasma levels of the soluble form of CLEC-2, generated by protease cleavage, are risk factors for coronary artery disease, and prognostic indicators of vascular events in patients with acute ischemic stroke and cancer (Fei et al, 2020; Inoue et al, 2019; Wu et al, 2019b; Xiong et al, 2016). The gene discussed is CLEC1B; the disease is cancer.