POU5F1 and colorectal carcinoma: It is noteworthy that Yes-associated protein 1 (YAP1) and octamer-binding transcription factor 4 (Oct4) jointly upregulate EMT-activating factors (Bora-Singhal et al. 2015; Chang et al. 2022), with YAP1 overexpression linked to tumorigenicity, metastasis, and chemoresistance in CRC cells (Li et al. 2018; Ji et al. 2023).