AKT1 and nicotine dependence: DEGs from pedB samples showed enrichment for pathways including NOTCH, MAPK, PI3K-AKT, RAS, RAP1, and Calcium signaling, pathways involving ion movement and downstream consequences (Nicotine addiction, Morphine addiction, GABAergic synapse), as well as pathways involving local interactions (ECM-receptor interaction, Focal adhesion).