TGFB1 and hepatocellular carcinoma: Therefore, a deficiency of ferritin elevates the Fe2+ level in the cytoplasm, which triggers the Fenton reaction and ROS generation.[10] According to the previous report, TGFβ1 can lead to a depletion of intracellular glutathione by downregulating xCT, an essential component of the cystine/glutamate antiporter, thereby inducing ferroptosis in hepatocellular carcinoma cells.[41] Here we discovered that TGFβ2 induces lipid peroxidation and ferroptotic damage in SGOs, accompanied by a marked decrease in ferritin levels.