FOXP3 and colitis: Previously, SEA has been shown to significantly reduce the severity of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis [51] and dextran sulfate sodium (DSS)-induced colitis [49] in a mouse model by increasing the number of FoxP3+ Treg cells and secretion of Th2 cytokines, including IL-10 [49].