GCG and obesity due to melanocortin 4 receptor deficiency: For instance, GPR43 has been found toprotect against diet-induced obesity in mice.229,230 Activation of GPR43 on L-cells leads to an increase in the secretionof glucagon-like peptide-1 (GLP-1),231,232 and acetatehas been shown to induce antilipolytic activity233 and improve glucose and lipid metabolism229 through GPR43 in white adipose tissue (WAT).