MYH11 and SYNPO2 linked to EMILIN1-related Connective Tissue Disease, AOC3 and MYH11 linked to Autosomal Dominant Cutis Laxa, MYH11 and SYNPO2 linked to Lethal Arteriopathy Syndrome due to Fibulin-4 Deficiency, while AOC3 and TAGLN linked to Renal Tubular Dysgenesis of Genetic Origin (Fig 2). This evidence concerns the gene SYNPO2 and connective tissue disorder.