Adding the causal genes ACE, AGT, AGTR1, and REN to list 2+ (n = 9+4) revealed AOC3 with at least one causal gene to be associated with Transition Metal Ion Binding (GO:0046914, q = 2.288x10-2), and Atherosclerosis (q = 2.821x10-5). This evidence concerns the gene ACE and atherosclerosis.