Low-risk features MSI without BRAF mutationHigh-risk features LVI or PNI Mucinous or Signet Histology Poorly differentiated histology Bowel obstruction Tumor perforation <12 lymph nodes examined*Tumor deposits considered as N+ disease *Consider chemotherapy before transplantation for high-risk stage 2 disease*Patients with stage 3 disease should complete chemotherapy. Here, BRAF is linked to neoplasm.