S100A8 and hydrops fetalis: The Xenium keratinocyte clusters Activated HF, Activated Suprabasal 1, and Activated Suprabasal 2 expressed genes involved in wound-responsive keratinocyte activation, such as keratins (Krt6a/b, Krt16), inflammation-related (S100a8, Il1b, Il1rn, Slpi), and basal/oral like keratinocyte markers (Dsc2, Aldh1a3, Krt4, Tgm3) (Supplemental Figure 13D) (26).