PIK3R3 and hydrops fetalis: There were proportionally fewer IFE Suprabasal (Krt10, Serpinb3b), Upper HF Suprabasal (Cst6, Defb6), and HF Stem Cell 2 (Cd34, Tgm5) cells and more Lower HF 1 & 2 (Sox5, Ptch1; Lef, Pik3r3, respectively) PITX1+ keratinocytes (Figure 7A).