Discovered originally as an actin binding/remodeling protein in breast cancers (50, 51) and found later to directly bind microtubules and localize to cell junctions under bioenergetic stress (57), both actin and microtubule filaments may serve as highways for transport of GIV between MSCs and cancer cells, as described previously for motor proteins (15) within TNTs. The gene discussed is IMMT; the disease is breast cancer.