CCDC88A and neoplasm: Furthermore, we found that xenografted tumor cells depleted of GIV by CRISPR/Cas9 (Supplemental Figure 7, A and B) gained GIV protein (Supplemental Figure 7C), but not mRNA (Supplemental Figure 7D), presumably from high-GIV-expressing mouse stromal cells and/or co-implanted human mammary fibroblasts (arrows, Supplemental Figure 7C).