In this respect, it has been reported that the phosphorylation of FMNL2 by PKCα in S1072 is necessary for the secretion of the pro-metastatic factor Angiopoietin-like 4 (ANGPTL4) in breast cancer cells (Frank et al., 2023), which constitutes the first description for an activated formin involvement in secretion during cell invasion. The gene discussed is ANGPTL4; the disease is breast cancer.