In this respect, it has been reported that the phosphorylation of FMNL2 by PKCα in S1072 is necessary for the secretion of the pro-metastatic factor Angiopoietin-like 4 (ANGPTL4) in breast cancer cells (Frank et al., 2023), which constitutes the first description for an activated formin involvement in secretion during cell invasion. This evidence concerns the gene PRKCA and breast cancer.