HGPS patients and animal models with ubiquitous progerin expression show extensive cardiac alterations, including heart fibrosis and impaired cardiac electrical activity and function [reviewed in (Benedicto et al., 2021; Gordon et al., 1993; Hamczyk, del Campo, & Andres, 2018)]. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.