CDH5 and Hutchinson-Gilford progeria syndrome: To assess whether EC‐specific progerin expression in mice is sufficient to induce HGPS‐associated cardiovascular symptoms, we generated LmnaLCS/LCSCdh5‐CreERT2 mice by crossing LmnaLCS/LCS mice, which enable Cre‐dependent progerin expression (Osorio et al., 2011), with Cdh5‐CreERT2 mice, in which tamoxifen treatment activates Cre recombinase specifically in ECs (Sörensen et al., 2009).