Our previous studies (Del Campo et al., 2019, 2020; Hamczyk et al., 2024) and the results presented here show that EC‐specific progerin expression did not alter any cardiovascular parameter tested in three mouse models (LmnaLCS/LCSTie2Cre, LmnaLCS/LCSCdh5‐CreERT2, and Apoe−/−LmnaLCS/LCSCdh5‐CreERT2) that rely on two different strategies for EC‐specific Cre‐mediated recombination (Tie2 or Cdh5 promoter‐driven), either in atherosclerosis‐free or atheroprone mice (intact versus deleted Apoe gene). This evidence concerns the gene APOE and atherosclerosis.