Using this model, we showed that SM22α promoter‐driven progerin suppression and lamin A restoration in VSMCs prevents HGPS‐associated VSMC loss, vascular fibrosis, intimal leukocyte recruitment, aggravated atherosclerosis, and premature death (Benedicto et al., 2024; Sanchez‐Lopez et al., 2021). This evidence concerns the gene LMNA and atherosclerosis.