To test the effect of EC‐specific progerin expression on atherosclerosis development, we placed 2‐month‐old Apoe−/−LmnaLCS/LCSCdh5‐CreERT2 mice and Apoe−/−LmnaLCS/LCS controls on a high‐fat diet, and analyzed them at 4 months of age. Here, APOE is linked to atherosclerosis.