Our previous mouse studies showed that SM22α promoter‐driven progerin expression in VSMCs of Apoe‐deficient mice is sufficient to induce VSMC loss, vascular stiffening, adventitial thickening, and impaired arterial contraction and to aggravate atherosclerosis and provoke premature death (Del Campo et al., 2019, 2020; Hamczyk, Villa‐Bellosta, et al., 2018). This evidence concerns the gene APOE and atherosclerosis.