To assess whether EC‐specific progerin expression in mice is sufficient to induce HGPS‐associated cardiovascular symptoms, we generated LmnaLCS/LCSCdh5‐CreERT2 mice by crossing LmnaLCS/LCS mice, which enable Cre‐dependent progerin expression (Osorio et al., 2011), with Cdh5‐CreERT2 mice, in which tamoxifen treatment activates Cre recombinase specifically in ECs (Sörensen et al., 2009). The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.