LMNA and Hutchinson-Gilford progeria syndrome: In most HGPS patients, progeria is caused by a heterozygous de novo point mutation in the LMNA gene (c.1824C > T, p.G608G) that generates an aberrant splicing site which promotes the expression of progerin, a truncated version of the nuclear protein lamin A (De Sandre‐Giovannoli et al., 2003; Eriksson et al., 2003).