LMNA and atherosclerosis: Our mouse studies presented here show that progerin expression in ECs in vivo is not sufficient to induce features characteristic of HGPS such as defective postnatal growth, premature death, and cardiovascular alterations, including VSMC loss, an elevated adventitia/media ratio, medial collagen accumulation, excessive atherosclerosis, heart fibrosis, and cardiac dysfunction and electrical alterations.