UCP1 and obesity due to melanocortin 4 receptor deficiency: Recent investigations in animal models of obesity have revealed that RJ combats obesity and related comorbidities by increasing thermogenesis and producing beige adipose tissue (white fat browning effect) by upregulating thermogenic genes, including uncoupling protein 1 (UCP‐1) and other downstream transcription factors, like PR domain containing 16 (PRDM‐16), p38 mitogen‐activated protein kinases (p38 MAPK), and bone morphogenetic protein 8B (BMP8B) (Mesri Alamdari et al., 2020; Yoneshiro et al., 2018).