The authors reported in a recent investigation that RJ is capable of inducing thermogenesis by increasing the expression of thermogenic factors, including UCP‐1, PRDM‐16, p38 MAPK, and other downstream genes, which gave rise to the remodeling of white fat and the activation of classical brown fat in an obesity model of HFD‐induced rats (Mesri Alamdari et al., 2020). Here, PRDM16 is linked to obesity due to melanocortin 4 receptor deficiency.