Although the exact mechanisms of the relationship between increased body fat and insulin resistance are not fully understood, it is proposed that enhanced amounts of free fatty acids play an important role by disturbing the glycolytic pathway and impairing glucose attraction to the cells, utilization, and oxidation in tissues that are sensitive to insulin (Pratchayasakul et al., 2011; Silveira et al., 2008). Here, INS is linked to Insulin resistance.