The phosphatidylinositide‐3 kinase (PI3K)/Akt signaling pathway is tightly engaged in the regulation of cellular metastasis; hence, the invasion, metastasis, and expansion of tumor cells can be restricted by dysregulating the PI3K/Akt and MAPK signaling pathways (Kciuk et al., 2022). The gene discussed is AKT1; the disease is neoplasm.