In GK rats with spontaneous T2DM that were administered agiophyllum oligosaccharides (AOS; 0.96, 0.48, and 0.24 g/kg) via gastric administration, insulin release was promoted, islet apoptosis was inhibited, islet function was improved, and random blood glucose levels were significantly reduced after 8 weeks of AOS administration (Bao & Han, 2016). This evidence concerns the gene INS and type 2 diabetes mellitus.