However, increased LH suppresses the endothelial nitric oxide synthase (eNOS)‐nitric oxide (NO)‐cyclic guanosine monophosphate (cGMP) signaling pathway, resulting in lipid accumulation (Meng et al., 2019), and FSH induces dyslipidemia through inhibiting hepatic cholesterol metabolism (Song et al., 2016). Here, NOS3 is linked to metabolic syndrome.