Furthermore, individuals with depression have significantly higher levels of inflammatory cytokines (40), such as interleukin-1 (IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which are also important mediators in the pathogenesis of asthma (41). The gene discussed is IL4; the disease is depressive disorder.