INS and diabetes mellitus: Initial treatment concerned insulin (1.06 UI/kg, glargine total dose 14 UI/day, lispro total dose 36 UI/day), quickly titrated to high doses (3.13 UI/kg, glargine total dose 52 UI/day, lispro total dose 95 UI/day) because diabetes was not adequately controlled at ambulatory glucose profile [AGP; time in the range (TIR) 5%, time above range (TAR) 95%, time below range (TBR) 0%, glucose management indicator (GMI) 11.3%]; metformin (1 g/day) and semaglutide (0.25 mg/week) were added.