TGFB1 and pulmonary fibrosis: Research has shown that lncRNA MIR155HG is abnormally upregulated in pulmonary fibrosis tissues and normal human primary lung fibroblasts (NHLFs) stimulated by TGF-β1; it binds directly to mir-627 to inhibit its expression, enhancing TGF-β1-induced high mobility group box-1 protein (HMGB1) expression, p65 phosphorylation, NHLFs proliferation, and extracellular matrix (ECM) deposition (Li et al., 2021).