ATRX and astrocytic tumor: The combination of IDH1R132H/p53mut and ATRX loss induces immune escape by upregulating immune checkpoint proteins such as PD-L1, PD-L2, and the BET protein BRD3/4 in astrogliomas, as well as cytokines and chemokines such as IL-33, CXCL8, CSF2, IL-6, and CXCL9 (Hu et al., 2022).