ATRX syndrome manifests as multiple bodily system abnormalities (Badens et al., 2006; Gibbons et al., 2008; Dhayalan et al., 2011; Palaniappan and Ramalingam, 2017; Bieluszewska et al., 2022), which are related to various factors, such as ATRX structural alterations, interacting proteins, and the regulation of gene expression. This evidence concerns the gene ATRX and alpha thalassemia-X-linked intellectual disability syndrome.