According to genome aberrations, high-risk neuroblastomas can be divided into four categories: MYCN amplification (37%), TERT rearrangement (23%), lack of ATRX (11%), and not mutant (29%) (Brodeur, 2003; Cheung and Dyer, 2013; Zeineldin et al., 2020). The gene discussed is ATRX; the disease is neuroblastoma.