Our previous study proved that Pantoprazole administration reduces the expression of GST-P and PCNA, significantly decreases exosomal RAB11A mRNA levels, along with downregulating exosomal Lnc-RNA-RP11-513I15.6, which were found to be elevated in the HCC animal model (Matboli et al., 2019). This evidence concerns the gene PCNA and hepatocellular carcinoma.