To examine the role of SPOP in UBC, we analyzed the frequency of SPOP genetic alterations in TCGA-BLCA dataset containing 127 samples with genetic information, and found that only 2.4% of UBC patients had genetic alterations, including X27 splicing and E210Q (within the BTB domain; Figure S1A-B). The gene discussed is SPOP; the disease is bladder transitional cell carcinoma.