In our study, we identified the presence of the PANoptosome in sorafenib-treated LV-D HCC cells, which was composed of essential PANoptotic proteins, including Pyrin, receptor-interacting protein kinase 1 (RIPK1), and caspase-8 (Figure 3M and S4C). The gene discussed is CASP8; the disease is hepatocellular carcinoma.