VSMC-specific-deleting Gasdermin D (GSDMD), a fundamental executive pore-forming protein in pyroptosis, which is a form of programmed cell death tightly linked to inflammation, alleviates Angiotensin II (Ang II)-induced AAA in apolipoprotein E knock-out (ApoE-/-) mice 10-12. This evidence concerns the gene GSDMD and triple-A syndrome.