SIRT7 and cancer: SIRT7 is overexpressed in invasive breast cancer, esophageal cancer, renal cell carcinoma, clear cell renal cell carcinoma, lung adenocarcinoma, prostate adenocarcinoma, HCC, thyroid carcinoma, cholangiocarcinoma, uterine corpus cancer, and gastric adenocarcinoma.166 SIRT7 promotes cancer cell proliferation and metabolism primarily by promoting ribosome biogenesis.