SIRT1 and melanoma: It has been shown that tenovin-1 and tenovin-6 act by inhibiting the protein deacetylation activity of SIRT1 and SIRT2, leading to a decrease in the expression of the mitotic checkpoint regulators BUB3, BUB1, and BUBR1, which is capable of slowing down the growth of tumors from highly aggressive melanoma cell lines 268.