SIRT6 and neoplasm: Males absent on the first (MOF) -mediated acetylation of SIRT6, resulting in reduced SIRT6 deacetylase activity, impedes the interaction of SIRT6 with the transcription factor FOXA2 and leads to transcriptional activation of ZEB2, which ultimately attenuates the tumor-suppressor function of SIRT6 in NSCLC and promotes NSCLC progression 100.