Recently, another study demonstrated that SIRT6 protein levels are negatively correlated with anoikisa, a form of apoptosis significant to cancer metastasis, and mechanistically SIRT6 inhibits apoptosis in by down-regulating the transcription of N-myc downstream regulated gene 1 (NDRG1) which is a negative regulator of the AKT signaling pathway 210. The gene discussed is SIRT6; the disease is cancer.