Furthermore, SIRT5 increases ROS levels and NADP/NADPH ratios in GC cells, desuccinylates 2-oxoglutarate dehydrogenase (OGDH), downregulates its activity, decreases mitochondrial membrane potential (ΔΨm), an ATP product, and interferes with mitochondrial function and redox state to prevent GC cell growth and migration 156. Here, SIRT5 is linked to gastric cancer.