A novel SIRT2 inhibitor, AGK2, was identified in the pathogenesis of Parkinson's disease (PD), and AGK 2 differed from Sirtinol, an inhibitor of SIRT2, by a significant up-regulation of acetylation modifications and an increase in the level of acetylated microtubule proteins 272. This evidence concerns the gene SIRT2 and Parkinson disease.