OGDH and gastric cancer: Furthermore, SIRT5 increases ROS levels and NADP/NADPH ratios in GC cells, desuccinylates 2-oxoglutarate dehydrogenase (OGDH), downregulates its activity, decreases mitochondrial membrane potential (ΔΨm), an ATP product, and interferes with mitochondrial function and redox state to prevent GC cell growth and migration 156.