SQSTM1 and obesity due to melanocortin 4 receptor deficiency: Although many studies have shown that p62 is involved in energy homeostasis and glucose/lipid metabolism in vivo, only one study has reported that whole-brain p62 deficiency leads to hyperphagia and obesity 20; therefore, the role of p62 in whole-body metabolism and signal transduction pathways in specific neuronal populations has not been fully elucidated.