SQSTM1 and obesity due to melanocortin 4 receptor deficiency: This model recapitulated the anti-obesity outcomes previously noted in MBH AAV9-p62 WT mice, underscoring the central role of MBH p62 expression in mitigating obesity indicators, including decreased energy intake, BW and fat mass, alongside increased rectal temperature and energy expenditure (Fig. 3B-H), signifying enhanced metabolic health.