Overexpressed LDHA exhibited the immunosuppressive effects in cancer cells, which can activate tumor-associated fibroblasts (TAFs) and impede drug penetration, thereby diminishing the efficacy of DOX-induced ICD, Wu et al. have developed a strategy using LDHA as a molecular imprinting template to create a surface-imprinted polymer, LDHA@MIP-DSD 115. Here, LDHA is linked to cancer.