A recent study showed that inhibition of HIF1A expression reduces stimulator of interferon gene (STING) associated proinflammatory molecule expression of macrophages in an EAM model, indicating that STING activates proinflammatory macrophage via HIF1A and herein promotes the development of autoimmune myocarditis (26). The gene discussed is HIF1A; the disease is autoimmune myocarditis.